AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformations

AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformations

Abstract Background Venous malformations (VMs), most of which associated with activating mutations in the endothelial cells (ECs) tyrosine kinase receptor TIE2, are characterized by dilated and immature veins with scarce smooth muscle cells (SMCs) coverage. However, the underlying mechanism of inter...

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Bibliographic Details
Main Authors: Yameng Si, Jiadong Huang, Xiang Li, Yu Fu, Rongyao Xu, Yifei Du, Jie Cheng, Hongbing Jiang
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Cell Communication and Signaling
Subjects:
Venous malformation
AKT
FOXO1
Endothelial cells
Smooth muscle cells
TIE2-L914F
Online Access:http://link.springer.com/article/10.1186/s12964-020-00606-w

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http://link.springer.com/article/10.1186/s12964-020-00606-w

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