Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors

Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors

Cardiac progenitor cells (CPCs) must control their number and fate to sustain the rapid heart growth during development, yet the intrinsic factors and environment governing these processes remain unclear. Here, we show that deletion of the ancient cell-fate regulator Numb (Nb) and its homologue Numb...

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Bibliographic Details
Main Authors: Lincoln T Shenje, Peter Andersen, Hideki Uosaki, Laviel Fernandez, Peter P Rainer, Gun-sik Cho, Dong-ik Lee, Weimin Zhong, Richard P Harvey, David A Kass, Chulan Kwon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-04-01
Series:eLife
Subjects:
cardiac progenitor
self-renewal
niche
numb
microenvironment
heart
Online Access:https://elifesciences.org/articles/02164

Internet

https://elifesciences.org/articles/02164

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