The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512

The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512

Objective: Insulin release from pancreatic islet β cells should be tightly controlled to avoid hypoglycemia and insulin resistance. The cortical actin cytoskeleton is a gate for regulated exocytosis of insulin secretory granules (SGs) by restricting their mobility and access to the plasma membrane....

Full description

Bibliographic Details
Main Authors: Hassan Mziaut, Bernard Mulligan, Peter Hoboth, Oliver Otto, Anna Ivanova, Maik Herbig, Desiree Schumann, Tobias Hildebrandt, Jaber Dehghany, Anke Sönmez, Carla Münster, Michael Meyer-Hermann, Jochen Guck, Yannis Kalaidzidis, Michele Solimena
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877816300527

Internet

http://www.sciencedirect.com/science/article/pii/S2212877816300527

Similar Items