Mutational change of CTX‐M‐15 to CTX‐M‐127 resulting in mecillinam resistant Escherichia coli during pivmecillinam treatment of a patient

Mutational change of CTX‐M‐15 to CTX‐M‐127 resulting in mecillinam resistant Escherichia coli during pivmecillinam treatment of a patient

Abstract Pivmecillinam (amdinocillin pivoxil) is the recommended first‐choice antibiotic used to treat urinary tract infections (UTIs) in Denmark. The frequency of mutation to mecillinam (MEC) resistance is described as high in vitro; however, treatment of UTI has a good clinical response and preval...

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Bibliographic Details
Main Authors: Karen Leth Nielsen, Katrine Hartung Hansen, Jesper Boye Nielsen, Jenny Dahl Knudsen, Kristian Schønning, Niels Frimodt‐Møller, Frederik Boëtius Hertz, Filip Jansåker
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:MicrobiologyOpen
Subjects:
Escherichia coli
LPS
mecillinam
metabolism
mutation
O‐antigen
Online Access:https://doi.org/10.1002/mbo3.941

Internet

https://doi.org/10.1002/mbo3.941

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