Intrastriatal botulinum toxin abolishes pathologic rotational behaviour and induces axonal varicosities in the 6-OHDA rat model of Parkinson's disease

Intrastriatal botulinum toxin abolishes pathologic rotational behaviour and induces axonal varicosities in the 6-OHDA rat model of Parkinson's disease

Central pathophysiological pathways of basal ganglia dysfunction imply a disturbed interaction of dopaminergic and cholinergic circuits. In Parkinson's disease (PD) imbalanced cholinergic hyperactivity prevails in the striatum. Interruption of acetylcholine (ACh) release in the striatum by loca...

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Bibliographic Details
Main Authors: Andreas Wree, Eilhard Mix, Alexander Hawlitschka, Veronica Antipova, Martin Witt, Oliver Schmitt, Reiner Benecke
Format: Article
Language:English
Published: Elsevier 2011-02-01
Series:Neurobiology of Disease
Subjects:
Botulinum neurotoxin A
6-Hydroxy dopamine
Striatum
Motor function
Apomorphine-induced rotation
Axonal varicosities
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110003189

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http://www.sciencedirect.com/science/article/pii/S0969996110003189

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