Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling

Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling

Pericytes are perivascular mural cells that enwrap brain capillaries and maintain blood-brain barrier (BBB) integrity. Most studies suggest that pericytes regulate cerebral blood flow (CBF) and oxygen delivery to activated brain structures, known as neurovascular coupling. While we have previously s...

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Bibliographic Details
Main Authors: Kassandra Kisler, Angeliki M. Nikolakopoulou, Melanie D. Sweeney, Divna Lazic, Zhen Zhao, Berislav V. Zlokovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neurovascular coupling
acute pericyte ablation
cerebral blood flow
capillary
laser doppler flowmetry
intrinsic optical signal imaging
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00027/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00027/full

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