PRG5 Knockout Precipitates Late-Onset Hypersusceptibility to Pilocarpine-Induced Juvenile Seizures by Exacerbating Hippocampal Zinc Signaling-Mediated Mitochondrial Damage

PRG5 Knockout Precipitates Late-Onset Hypersusceptibility to Pilocarpine-Induced Juvenile Seizures by Exacerbating Hippocampal Zinc Signaling-Mediated Mitochondrial Damage

IntroductionEpileptogenesis is understood as the plastic process that produces a persistent reorganization of the brain’s neural network after a precipitating injury (recurrent neonatal seizures, for instance) with a latent period, finally leading to neuronal hyperexcitability. Plasticity-related ge...

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Bibliographic Details
Main Authors: Dandan Wang, Mei-fang Jin, Lili Li, Yueying Liu, Yuxiao Sun, Hong Ni
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Neuroscience
Subjects:
zinc signaling
hippocampal mossy fiber sprouting
hypersusceptibility
PRG5
developmental seizure
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.715555/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.715555/full

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