Characterisation of the Broadly-Specific O-Methyl-transferase JerF from the Late Stages of Jerangolid Biosynthesis

Characterisation of the Broadly-Specific O-Methyl-transferase JerF from the Late Stages of Jerangolid Biosynthesis

We describe the characterisation of the O-methyltransferase JerF from the late stages of jerangolid biosynthesis. JerF is the first known example of an enzyme that catalyses the formation of a non-aromatic, cyclic methylenolether. The enzyme was overexpressed in E. coli and the cell-free extracts we...

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Bibliographic Details
Main Authors: Steffen Friedrich, Franziska Hemmerling, Frederick Lindner, Anna Warnke, Johannes Wunderlich, Gesche Berkhan, Frank Hahn
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:Molecules
Subjects:
methyltransferases
enzymes
chemoenzymatic synthesis
natural products
chemoselectivity
methylenolethers
Online Access:http://www.mdpi.com/1420-3049/21/11/1443

Internet

http://www.mdpi.com/1420-3049/21/11/1443

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