Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms

Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms

Summary: Organismal stressors such as cold exposure require a systemic response to maintain body temperature. Brown adipose tissue (BAT) is a key thermogenic tissue in mammals that protects against hypothermia in response to cold exposure. Defining the complex interplay of multiple organ systems in...

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Bibliographic Details
Main Authors: Jaimarie Sostre-Colón, Kahealani Uehara, Anna E. Garcia Whitlock, Matthew J. Gavin, Jeff Ishibashi, Matthew J. Potthoff, Patrick Seale, Paul M. Titchenell
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports
Subjects:
liver insulin signaling
cold sensitivity
FGF21
FOXO1
lipolysis
thermogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721004678

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http://www.sciencedirect.com/science/article/pii/S2211124721004678

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