Identifying Signalling Pathways Regulated by GPRC5B in β-Cells by CRISPR-Cas9-Mediated Genome Editing

Identifying Signalling Pathways Regulated by GPRC5B in β-Cells by CRISPR-Cas9-Mediated Genome Editing

Background/Aims: CRISPR-Cas9, a RNA-guided targeted genome editing tool, has revolutionized genetic engineering by offering the ability to precisely modify DNA. GPRC5B is an orphan receptor belonging to the group C family of G protein-coupled receptors (GPCRs). In this study, we analysed the functio...

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Bibliographic Details
Main Authors: Patricio Atanes, Inmaculada Ruz-Maldonado, Ross Hawkes, Bo Liu, Shanta J. Persaud, Stefan Amisten
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-01-01
Series:Cellular Physiology and Biochemistry
Subjects:
β-cell
GPRC5B
CRISPR-Cas9
Apoptosis
Proliferation
Type 2 diabetes
Online Access:https://www.karger.com/Article/FullText/487159

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https://www.karger.com/Article/FullText/487159

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