Extracellular gamma-synuclein promotes tumor cell motility by activating β1 integrin-focal adhesion kinase signaling pathway and increasing matrix metalloproteinase-24, -2 protein secretion

Extracellular gamma-synuclein promotes tumor cell motility by activating β1 integrin-focal adhesion kinase signaling pathway and increasing matrix metalloproteinase-24, -2 protein secretion

Abstract Background Increasing evidence reveals a significant correlation between gamma-synuclein (SNCG) level and tumor invasion and metastasis in various human cancers. Our previous investigation showed that SNCG could secrete into extracellular environment and promoted tumor cell motility, but th...

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Bibliographic Details
Main Authors: Caiyun Liu, Like Qu, Chuanke Zhao, Chengchao Shou
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Gamma-synuclein
β1 integrin
Focal adhesion kinase
MMP-2
Motility
Activation
Online Access:http://link.springer.com/article/10.1186/s13046-018-0783-6

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