Extracellular gamma-synuclein promotes tumor cell motility by activating β1 integrin-focal adhesion kinase signaling pathway and increasing matrix metalloproteinase-24, -2 protein secretion

Extracellular gamma-synuclein promotes tumor cell motility by activating β1 integrin-focal adhesion kinase signaling pathway and increasing matrix metalloproteinase-24, -2 protein secretion

Abstract Background Increasing evidence reveals a significant correlation between gamma-synuclein (SNCG) level and tumor invasion and metastasis in various human cancers. Our previous investigation showed that SNCG could secrete into extracellular environment and promoted tumor cell motility, but th...

Full description

Bibliographic Details
Main Authors: Caiyun Liu, Like Qu, Chuanke Zhao, Chengchao Shou
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Gamma-synuclein
β1 integrin
Focal adhesion kinase
MMP-2
Motility
Activation
Online Access:http://link.springer.com/article/10.1186/s13046-018-0783-6

Internet

http://link.springer.com/article/10.1186/s13046-018-0783-6

Similar Items