Role of RecA and the SOS response in thymineless death in Escherichia coli.

Thymineless death (TLD) is a classic and enigmatic phenomenon, documented in bacterial, yeast, and human cells, whereby cells lose viability rapidly when deprived of thymine. Despite its being the essential mode of action of important chemotherapeutic agents, and despite having been studied extensiv...

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Bibliographic Details
Main Authors: Natalie C Fonville, David Bates, P J Hastings, Philip C Hanawalt, Susan M Rosenberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2832678?pdf=render