Disruption of the Putative Ribosome-Binding Motif of a Scaffold Protein Impairs Cytochrome c Oxidase Subunit Expression in Leishmania major

Disruption of the Putative Ribosome-Binding Motif of a Scaffold Protein Impairs Cytochrome c Oxidase Subunit Expression in Leishmania major

Leishmania parasites are trypanosomatid protozoans that persist in infected human hosts to cause a spectrum of pathologies, from cutaneous and mucocutaneous manifestations to visceral leishmaniasis caused by Leishmania donovani. The latter is usually fatal if not treated. Persistence of L. major in...

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Bibliographic Details
Main Authors: Daviel Cardenas, Charity Sylvester, Bo Cao, Catherine S. Nation, Juan C. Pizarro, Hua Lu, Jessie Guidry, Edward J. Wojcik, Ben L. Kelly
Format: Article
Language:English
Published: American Society for Microbiology 2019-03-01
Series:mSphere
Subjects:
LACK
Leishmania
RACK1
cytochrome c oxidase
mitochondria
parasite
ribosome
translation
Online Access:https://doi.org/10.1128/mSphere.00644-18

Internet

https://doi.org/10.1128/mSphere.00644-18

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