Toward an Understanding of the Structural and Mechanistic Aspects of Protein-Protein Interactions in 2-Oxoacid Dehydrogenase Complexes

Toward an Understanding of the Structural and Mechanistic Aspects of Protein-Protein Interactions in 2-Oxoacid Dehydrogenase Complexes

The 2-oxoglutarate dehydrogenase complex (OGDHc) is a key enzyme in the tricarboxylic acid (TCA) cycle and represents one of the major regulators of mitochondrial metabolism through NADH and reactive oxygen species levels. The OGDHc impacts cell metabolic and cell signaling pathways through the coup...

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Bibliographic Details
Main Authors: Natalia S. Nemeria, Xu Zhang, Joao Leandro, Jieyu Zhou, Luying Yang, Sander M. Houten, Frank Jordan
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Life
Subjects:
neurodegeneration
glucose metabolism
enzyme catalysis
protein-protein interaction
hydrogen exchange mass spectrometry
protein cross-linking
Online Access:https://www.mdpi.com/2075-1729/11/5/407

Internet

https://www.mdpi.com/2075-1729/11/5/407

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