LncRNA CDKN2B-AS1 stabilized by IGF2BP3 drives the malignancy of renal clear cell carcinoma through epigenetically activating NUF2 transcription

LncRNA CDKN2B-AS1 stabilized by IGF2BP3 drives the malignancy of renal clear cell carcinoma through epigenetically activating NUF2 transcription

Abstract Because of the lack of sensitivity to radiotherapy and chemotherapy, therapeutic options for renal clear cell carcinoma (KIRC) are scarce. Long noncoding RNAs (lncRNAs) play crucial roles in the progression of cancer. However, their functional roles and upstream mechanisms in KIRC remain la...

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Bibliographic Details
Main Authors: Xina Xie, Jiatian Lin, Xiaoqin Fan, Yuantang Zhong, Yequn Chen, Kaiqing Liu, Yonggang Ren, Xiangling Chen, Daihuan Lai, Xuyi Li, Zesong Li, Aifa Tang
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03489-y

Internet

https://doi.org/10.1038/s41419-021-03489-y

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