Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity

Elevated plasma LPS levels have been associated with insulin resistance. Here Cao et al. show that LPS induces ER stress and P300 activity via the XBP1/IRE1 pathway. P300 acetylates IRS1/2 and inhibits its binding with the insulin receptor. The consequent impairment of insulin signaling can be rescu...

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Main Authors:	Jia Cao, Jinghua Peng, Hongying An, Qiyi He, Tatiana Boronina, Shaodong Guo, Morris F. White, Philip A. Cole, Ling He
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-00163-w

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spelling	doaj-285554089e9548a3b4c4378a2f0a55552021-01-31T12:30:43ZengNature Publishing GroupNature Communications2041-17232017-07-018111210.1038/s41467-017-00163-wEndotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesityJia Cao0Jinghua Peng1Hongying An2Qiyi He3Tatiana Boronina4Shaodong Guo5Morris F. White6Philip A. Cole7Ling He8Division of Metabolism, Department of Pediatrics, Johns Hopkins University School of MedicineDivision of Metabolism, Department of Pediatrics, Johns Hopkins University School of MedicineDivision of Metabolism, Department of Pediatrics, Johns Hopkins University School of MedicineDepartment of Neuroscience, Brown UniversityDepartments of Biochemistry, Johns Hopkins University School of MedicineDepartment of Nutrition and Food Science, Texas A&M UniversityDivision of Endocrinology, Boston Children’s Hospital, Harvard UniversityDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University School of MedicineDivision of Metabolism, Department of Pediatrics, Johns Hopkins University School of MedicineElevated plasma LPS levels have been associated with insulin resistance. Here Cao et al. show that LPS induces ER stress and P300 activity via the XBP1/IRE1 pathway. P300 acetylates IRS1/2 and inhibits its binding with the insulin receptor. The consequent impairment of insulin signaling can be rescued by pharmacological inhibition of P300.https://doi.org/10.1038/s41467-017-00163-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jia Cao Jinghua Peng Hongying An Qiyi He Tatiana Boronina Shaodong Guo Morris F. White Philip A. Cole Ling He
spellingShingle	Jia Cao Jinghua Peng Hongying An Qiyi He Tatiana Boronina Shaodong Guo Morris F. White Philip A. Cole Ling He Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity Nature Communications
author_facet	Jia Cao Jinghua Peng Hongying An Qiyi He Tatiana Boronina Shaodong Guo Morris F. White Philip A. Cole Ling He
author_sort	Jia Cao
title	Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity
title_short	Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity
title_full	Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity
title_fullStr	Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity
title_full_unstemmed	Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity
title_sort	endotoxemia-mediated activation of acetyltransferase p300 impairs insulin signaling in obesity
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-07-01
description	Elevated plasma LPS levels have been associated with insulin resistance. Here Cao et al. show that LPS induces ER stress and P300 activity via the XBP1/IRE1 pathway. P300 acetylates IRS1/2 and inhibits its binding with the insulin receptor. The consequent impairment of insulin signaling can be rescued by pharmacological inhibition of P300.
url	https://doi.org/10.1038/s41467-017-00163-w
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Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity

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