Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity

Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity

Elevated plasma LPS levels have been associated with insulin resistance. Here Cao et al. show that LPS induces ER stress and P300 activity via the XBP1/IRE1 pathway. P300 acetylates IRS1/2 and inhibits its binding with the insulin receptor. The consequent impairment of insulin signaling can be rescu...

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Bibliographic Details
Main Authors: Jia Cao, Jinghua Peng, Hongying An, Qiyi He, Tatiana Boronina, Shaodong Guo, Morris F. White, Philip A. Cole, Ling He
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00163-w

Internet

https://doi.org/10.1038/s41467-017-00163-w

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