The novel analogue of hirsutine as an anti-hypertension and vasodilatary agent both in vitro and in vivo.

In this paper, an analogue of hirsutine (compound 1) has been synthesized and evaluated as an anti-hypertension agent, which exhibits extraordinary effects on the contractile response of thoracic aorta rings from male SD rats in vitro (IC50 = 1.129×10(-9)±0.5025) and the abilities of reducing the sy...

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Bibliographic Details
Main Authors: Kai Zhu, Su-Na Yang, Fen-Fen Ma, Xian-Feng Gu, Yi-Chun Zhu, Yi-Zhun Zhu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4409389?pdf=render