The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation

Excessive inflammasome activation leads to inflammatory diseases, but how inflammasomes are regulated by PYD-only adaptors is unclear. Here the authors show that the PYD-only protein POP2 inhibits both inflammasome priming and assembly by interfering, respectively, with IκBα activation and NLRP3-ASC...

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Main Authors:	Rojo A. Ratsimandresy, Lan H. Chu, Sonal Khare, Lucia de Almeida, Anu Gangopadhyay, Mohanalaxmi Indramohan, Alexander V. Misharin, David R. Greaves, Harris Perlman, Andrea Dorfleutner, Christian Stehlik
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms15556

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spelling	doaj-28458afcf61a49ae89fbff053e45bdf42021-05-11T07:22:23ZengNature Publishing GroupNature Communications2041-17232017-06-018111510.1038/ncomms15556The PYRIN domain-only protein POP2 inhibits inflammasome priming and activationRojo A. Ratsimandresy0Lan H. Chu1Sonal Khare2Lucia de Almeida3Anu Gangopadhyay4Mohanalaxmi Indramohan5Alexander V. Misharin6David R. Greaves7Harris Perlman8Andrea Dorfleutner9Christian Stehlik10Division of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern UniversityDivision of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern UniversityDivision of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern UniversityDivision of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern UniversityDivision of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern UniversityDivision of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern UniversityDivision of Pulmonary and Critical Care, Department of Medicine, Feinberg School of Medicine, Northwestern UniversitySir William Dunn School of Pathology, University of OxfordDivision of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern UniversityDivision of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern UniversityDivision of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern UniversityExcessive inflammasome activation leads to inflammatory diseases, but how inflammasomes are regulated by PYD-only adaptors is unclear. Here the authors show that the PYD-only protein POP2 inhibits both inflammasome priming and assembly by interfering, respectively, with IκBα activation and NLRP3-ASC interaction.https://doi.org/10.1038/ncomms15556
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Rojo A. Ratsimandresy Lan H. Chu Sonal Khare Lucia de Almeida Anu Gangopadhyay Mohanalaxmi Indramohan Alexander V. Misharin David R. Greaves Harris Perlman Andrea Dorfleutner Christian Stehlik
spellingShingle	Rojo A. Ratsimandresy Lan H. Chu Sonal Khare Lucia de Almeida Anu Gangopadhyay Mohanalaxmi Indramohan Alexander V. Misharin David R. Greaves Harris Perlman Andrea Dorfleutner Christian Stehlik The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation Nature Communications
author_facet	Rojo A. Ratsimandresy Lan H. Chu Sonal Khare Lucia de Almeida Anu Gangopadhyay Mohanalaxmi Indramohan Alexander V. Misharin David R. Greaves Harris Perlman Andrea Dorfleutner Christian Stehlik
author_sort	Rojo A. Ratsimandresy
title	The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation
title_short	The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation
title_full	The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation
title_fullStr	The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation
title_full_unstemmed	The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation
title_sort	pyrin domain-only protein pop2 inhibits inflammasome priming and activation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-06-01
description	Excessive inflammasome activation leads to inflammatory diseases, but how inflammasomes are regulated by PYD-only adaptors is unclear. Here the authors show that the PYD-only protein POP2 inhibits both inflammasome priming and assembly by interfering, respectively, with IκBα activation and NLRP3-ASC interaction.
url	https://doi.org/10.1038/ncomms15556
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The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation

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