The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation

The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation

Excessive inflammasome activation leads to inflammatory diseases, but how inflammasomes are regulated by PYD-only adaptors is unclear. Here the authors show that the PYD-only protein POP2 inhibits both inflammasome priming and assembly by interfering, respectively, with IκBα activation and NLRP3-ASC...

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Bibliographic Details
Main Authors: Rojo A. Ratsimandresy, Lan H. Chu, Sonal Khare, Lucia de Almeida, Anu Gangopadhyay, Mohanalaxmi Indramohan, Alexander V. Misharin, David R. Greaves, Harris Perlman, Andrea Dorfleutner, Christian Stehlik
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15556

Internet

https://doi.org/10.1038/ncomms15556

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