A DNA vaccine encoding multiple HIV CD4 epitopes elicits vigorous polyfunctional, long-lived CD4+ and CD8+ T cell responses.

A DNA vaccine encoding multiple HIV CD4 epitopes elicits vigorous polyfunctional, long-lived CD4+ and CD8+ T cell responses.

T-cell based vaccines against HIV have the goal of limiting both transmission and disease progression by inducing broad and functionally relevant T cell responses. Moreover, polyfunctional and long-lived specific memory T cells have been associated to vaccine-induced protection. CD4(+) T cells are i...

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Bibliographic Details
Main Authors: Daniela Santoro Rosa, Susan Pereira Ribeiro, Rafael Ribeiro Almeida, Eliane Conti Mairena, Edilberto Postól, Jorge Kalil, Edecio Cunha-Neto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3037933?pdf=render

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http://europepmc.org/articles/PMC3037933?pdf=render

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