Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis.
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disorder characterized by fibroproliferation and excessive accumulation of extracellular matrix in the lung. METHODS AND FINDINGS: Using oligonucleotide arrays, we identified osteopontin as one of the genes that significantl...
| Format: | Article |
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| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-09-01
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| Series: | PLoS Medicine |
| Online Access: | http://dx.doi.org/10.1371/journal.pmed.0020251 |