Beneficial Effects of Mineralocorticoid Receptor Antagonism on Myocardial Fibrosis in an Experimental Model of the Myxomatous Degeneration of the Mitral Valve

Beneficial Effects of Mineralocorticoid Receptor Antagonism on Myocardial Fibrosis in an Experimental Model of the Myxomatous Degeneration of the Mitral Valve

Mitral valve prolapse (MVP) patients develop myocardial fibrosis that is not solely explained by volume overload, but the pathophysiology has not been defined. Mineralocorticoid receptor antagonists (MRAs) improve cardiac function by decreasing cardiac fibrosis in other heart diseases. We examined t...

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Bibliographic Details
Main Authors: Jaime Ibarrola, Mattie Garaikoetxea, Amaia Garcia-Peña, Lara Matilla, Eva Jover, Benjamin Bonnard, Maria Cuesta, Amaya Fernández-Celis, Frederic Jaisser, Natalia López-Andrés
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
myxomatous degeneration
cardiac fibrosis
mineralocorticoid receptor antagonist
collagen
proteoglycans
Online Access:https://www.mdpi.com/1422-0067/21/15/5372

Internet

https://www.mdpi.com/1422-0067/21/15/5372

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