Association Between Variants in Calcineurin Inhibitor Pharmacokinetic and Pharmacodynamic Genes and Renal Dysfunction in Adult Heart Transplant Recipients

Association Between Variants in Calcineurin Inhibitor Pharmacokinetic and Pharmacodynamic Genes and Renal Dysfunction in Adult Heart Transplant Recipients

Background: The goal of the study was to assess the relationship between single nucleotide variants (SNVs) in calcineurin inhibitor (CNI) pharmacokinetic and pharmacodynamic genes and renal dysfunction in adult heart transplant (HTx) recipients.Methods: This retrospective analysis included N = 192 p...

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Bibliographic Details
Main Authors: Kris Oreschak, Laura M. Saba, Nicholas Rafaels, Amrut V. Ambardekar, Kimberly M. Deininger, Robert L. Page, JoAnn Lindenfeld, Christina L. Aquilante
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Genetics
Subjects:
renal dysfunction
estimated glomerular filtration rate
heart transplant
pharmacogenetics
pharmacogenomics
calcineurin inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.658983/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.658983/full

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