Langerhans Cells Prevent Autoimmunity via Expansion of Keratinocyte Antigen-Specific Regulatory T Cells

Langerhans Cells Prevent Autoimmunity via Expansion of Keratinocyte Antigen-Specific Regulatory T Cells

Langerhans cells (LCs) are antigen-presenting cells in the epidermis whose roles in antigen-specific immune regulation remain incompletely understood. Desmoglein 3 (Dsg3) is a keratinocyte cell-cell adhesion molecule critical for epidermal integrity and an autoantigen in the autoimmune blistering di...

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Bibliographic Details
Main Authors: Daniela Y. Kitashima, Tetsuro Kobayashi, Therese Woodring, Kacey Idouchi, Thomas Doebel, Benjamin Voisin, Takeya Adachi, Takeshi Ouchi, Hayato Takahashi, Koji Nishifuji, Daniel H. Kaplan, Björn E. Clausen, Masayuki Amagai, Keisuke Nagao
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:EBioMedicine
Subjects:
Langerhans cells
Regulatory T cells
Autoimmune disease
Pemphigus
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417305030

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http://www.sciencedirect.com/science/article/pii/S2352396417305030

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