Quantitative proteomic analysis of Parkin substrates in Drosophila neurons

Quantitative proteomic analysis of Parkin substrates in Drosophila neurons

Abstract Background Parkin (PARK2) is an E3 ubiquitin ligase that is commonly mutated in Familial Parkinson’s Disease (PD). In cell culture models, Parkin is recruited to acutely depolarised mitochondria by PINK1. PINK1 activates Parkin activity leading to ubiquitination of multiple proteins, which...

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Bibliographic Details
Main Authors: Aitor Martinez, Benoit Lectez, Juanma Ramirez, Oliver Popp, James D. Sutherland, Sylvie Urbé, Gunnar Dittmar, Michael J. Clague, Ugo Mayor
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Molecular Neurodegeneration
Subjects:
Parkin (PARK2)
Parkin substrates
Ubiquitination
VPS35
Neurodegeneration
In vivo
Online Access:http://link.springer.com/article/10.1186/s13024-017-0170-3

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http://link.springer.com/article/10.1186/s13024-017-0170-3

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