The Fos-Related Antigen 1–JUNB/Activator Protein 1 Transcription Complex, a Downstream Target of Signal Transducer and Activator of Transcription 3, Induces T Helper 17 Differentiation and Promotes Experimental Autoimmune Arthritis

The Fos-Related Antigen 1–JUNB/Activator Protein 1 Transcription Complex, a Downstream Target of Signal Transducer and Activator of Transcription 3, Induces T Helper 17 Differentiation and Promotes Experimental Autoimmune Arthritis

Dysfunction of T helper 17 (Th17) cells leads to chronic inflammatory disorders. Signal transducer and activator of transcription 3 (STAT3) orchestrates the expression of proinflammatory cytokines and pathogenic cell differentiation from interleukin (IL)-17-producing Th17 cells. However, the pathway...

Full description

Bibliographic Details
Main Authors: Young-Mee Moon, Seon-Yeong Lee, Seung-Ki Kwok, Seung Hoon Lee, Deokhoon Kim, Woo Kyung Kim, Yang-Mi Her, Hea-Jin Son, Eun-Kyung Kim, Jun-Geol Ryu, Hyeon-Beom Seo, Jeong-Eun Kwon, Sue-Yun Hwang, Jeehee Youn, Rho H. Seong, Dae-Myung Jue, Sung-Hwan Park, Ho-Youn Kim, Sung-Min Ahn, Mi-La Cho
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
Fos-related antigen 1-JUNB
signal transducer and activator of transcription 3
T helper 17
autoimmune arthritis
inflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01793/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01793/full

Similar Items