GDF15 Regulates Malat-1 Circular RNA and Inactivates NFκB Signaling Leading to Immune Tolerogenic DCs for Preventing Alloimmune Rejection in Heart Transplantation

GDF15 Regulates Malat-1 Circular RNA and Inactivates NFκB Signaling Leading to Immune Tolerogenic DCs for Preventing Alloimmune Rejection in Heart Transplantation

Recombinant human growth differentiation factor 15 (rhGDF15) affects dendritic cell (DC) maturation. However, whether GDF15 is expressed in DCs and its roles and signaling in DCs remain largely unknown. It is unclear whether GDF15-DCs can induce immune tolerance in heart transplantation (HT). This s...

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Bibliographic Details
Main Authors: Yixin Zhang, Guangfeng Zhang, Yanling Liu, Renqi Chen, Duo Zhao, Vivian McAlister, Tina Mele, Kexiang Liu, Xiufen Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
GDF15
circular RNA
circ_Malat-1
tolerogenic DCs
heart transplantation
immune suppression
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02407/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02407/full

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