Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma

Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma

Abstract Background Glioblastoma is a disease with high heterogeneity that has long been difficult for doctors to identify and treat. ARHI is a remarkable tumor suppressor gene in human ovarian cancer and many other cancers. We found over-expression of ARHI can also inhibit cancer cell proliferation...

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Bibliographic Details
Main Authors: Chen Zhong, Mengting Shu, Junyi Ye, Xiaoxiong Wang, Xin Chen, Zhendong Liu, Wenyang Zhao, Boxian Zhao, Zhixing Zheng, Zhiqin Yin, Ming Gao, Haiqi Zhao, Kaikai Wang, Shiguang Zhao
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Cancer
Subjects:
ARHI
Autophagy
Apoptosis
Glioblastoma
Ras
Online Access:http://link.springer.com/article/10.1186/s12885-019-5643-z

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http://link.springer.com/article/10.1186/s12885-019-5643-z

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