A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions

A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions

Nucleic acid protection is a substantial challenge for neurons, which are continuously exposed to oxidative stress in the brain. Neurons require powerful mechanisms to protect DNA and RNA integrity and ensure their functionality and longevity. Beside its well known role in microtubule dynamics, we r...

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Bibliographic Details
Main Authors: Marie eViolet, Lucie eDelattre, Meryem eTardivel, Audrey eSultan, Alban eChauderlier, Raphaelle eCaillierez, Smail eTalahari, Fabrice eNesslany, Bruno eLefebvre, Eliette eBonnefoy, Luc eBuee, Marie-Christine eGalas
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
DNA Damage
DNA Repair
Oxidative Stress
hyperthermia
tau
RNA damage
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00084/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00084/full

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