Invariant Natural Killer T (iNKT) Cells Prevent Autoimmunity, but Induce Pulmonary Inflammation in Cystic Fibrosis

Invariant Natural Killer T (iNKT) Cells Prevent Autoimmunity, but Induce Pulmonary Inflammation in Cystic Fibrosis

Background/Aims: Inflammation is a major and critical component of the lung pathology in the hereditary disease cystic fibrosis. The molecular mechanisms of chronic inflammation in cystic fibrosis require definition. Methods: We used several genetic mouse models to test a role of iNKT cells and cera...

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Bibliographic Details
Main Authors: Nanna Siegmann, David Worbs, Frauke Effinger, Tobias Bormann, Madlen Gebhardt, Martina Ulrich, Fredrik Wermeling, Eva Müller-Hermelink, Tilo Biedermann, Mike Tighe, Michael J. Edwards, Charles Caldwell, Elizabeth Leadbetter, Mikael C. I. Karlsson, Katrin Anne Becker, Erich Gulbins, Gerd Döring
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Cystic fibrosis
Inflammation
Lung
Auto-immunity
iNKT-cells
Online Access:http://www.karger.com/Article/FullText/362984

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http://www.karger.com/Article/FullText/362984

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