Altered Transcriptional Control Networks with Trans-Differentiation of Isogenic Mutant KRas NSCLC Models

Altered Transcriptional Control Networks with Trans-Differentiation of Isogenic Mutant KRas NSCLC Models

BackgroundThe capacity of cancer cells to undergo epithelial mesenchymal trans-differentiation has been implicated as a factor driving metastasis, through the acquisition of enhanced migratory/invasive cell programs and the engagement of anti-apoptotic mechanisms promoting drug and radiation resista...

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Bibliographic Details
Main Authors: John A Haley, Elizabeth eHaughney, Erica eUllman, James eBean, John D. Haley, Marc eFink
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Oncology
Subjects:
Systems Biology
epigenetic
transcription
EMT
tumor heterogeneity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00344/full

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http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00344/full

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