Prophylactic inhibition of NF-κB expression in microglia leads to attenuation of hypoxic ischemic injury of the immature brain

Prophylactic inhibition of NF-κB expression in microglia leads to attenuation of hypoxic ischemic injury of the immature brain

Abstract Background Periventricular leukomalacia (PVL), a devastating brain injury affecting premature infants, is the most common cause of cerebral palsy. PVL is caused by hypoxia ischemia (HI) and is characterized by white matter necrotic lesions, microglial activation, upregulation of NF-κB, and...

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Bibliographic Details
Main Authors: Nahla Zaghloul, Dalibor Kurepa, Mohammad Y. Bader, Nadia Nagy, Mohamed N. Ahmed
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Journal of Neuroinflammation
Subjects:
Periventricular leukomalacia
White matter brain injury
Cerebral palsy
Hypoxia ischemia
NF-κB
Microglia
Online Access:https://doi.org/10.1186/s12974-020-02031-9

Internet

https://doi.org/10.1186/s12974-020-02031-9

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