Crude Fucoidan Extracts Impair Angiogenesis in Models Relevant for Bone Regeneration and Osteosarcoma via Reduction of VEGF and SDF-1

Crude Fucoidan Extracts Impair Angiogenesis in Models Relevant for Bone Regeneration and Osteosarcoma via Reduction of VEGF and SDF-1

The marine origin polysaccharide fucoidan combines multiple biological activities. As demonstrated by various studies in vitro and in vivo, fucoidans show anti-viral, anti-tumor, anti-oxidant, anti-inflammatory and anti-coagulant properties, although the detailed molecular action remains to be eluci...

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Bibliographic Details
Main Authors: Fanlu Wang, Harald Schmidt, Dijana Pavleska, Thees Wermann, Andreas Seekamp, Sabine Fuchs
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Marine Drugs
Subjects:
fucoidan
mesenchymal stem cells
outgrowth endothelial cells
co-culture
angiogenesis
bone formation
osteosarcoma
VEGF
SDF-1
Online Access:http://www.mdpi.com/1660-3397/15/6/186

Internet

http://www.mdpi.com/1660-3397/15/6/186

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