Increased copy number for methylated maternal 15q duplications leads to changes in gene and protein expression in human cortical samples

Increased copy number for methylated maternal 15q duplications leads to changes in gene and protein expression in human cortical samples

<p>Abstract</p> <p>Background</p> <p>Duplication of chromosome 15q11-q13 (dup15q) accounts for approximately 3% of autism cases. Chromosome 15q11-q13 contains imprinted genes necessary for normal mammalian neurodevelopment controlled by a differentially methylated impri...

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Bibliographic Details
Main Authors: Scoles Haley A, Urraca Nora, Chadwick Samuel W, Reiter Lawrence T, LaSalle Janine M
Format: Article
Language:English
Published: BMC 2011-12-01
Series:Molecular Autism
Subjects:
autism
imprinting
copy number variation
15q
duplication
methylation
epigenetic
Online Access:http://www.molecularautism.com/content/2/1/19

Internet

http://www.molecularautism.com/content/2/1/19

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