First small-molecule PROTACs for G protein-coupled receptors: inducing α1A-adrenergic receptor degradation

First small-molecule PROTACs for G protein-coupled receptors: inducing α1A-adrenergic receptor degradation

Proteolysis targeting chimeras (PROTACs) are dual-functional hybrid molecules that can selectively recruit an E3 ubiquitin ligase to a target protein to direct the protein into the ubiquitin-proteasome system (UPS), thereby selectively reducing the target protein level by the ubiquitin-proteasome pa...

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Bibliographic Details
Main Authors: Zhenzhen Li, Yuxing Lin, Hui Song, Xiaojun Qin, Zhongxia Yu, Zheng Zhang, Gaopan Dong, Xiang Li, Xiaodong Shi, Lupei Du, Wei Zhao, Minyong Li
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Small-molecule PROTACs
α1A-Adrenergic receptor
Ubiquitylation
Degradation
Prostate cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383519313188

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http://www.sciencedirect.com/science/article/pii/S2211383519313188

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