Chenodeoxycholic Acid Ameliorates AlCl<sub>3</sub>-Induced Alzheimer’s Disease Neurotoxicity and Cognitive Deterioration via Enhanced Insulin Signaling in Rats

Chenodeoxycholic Acid Ameliorates AlCl<sub>3</sub>-Induced Alzheimer’s Disease Neurotoxicity and Cognitive Deterioration via Enhanced Insulin Signaling in Rats

Insulin resistance is a major risk factor for Alzheimer&#8217;s disease (AD). Chenodeoxycholic acid (CDCA) and synthetic Farnesoid X receptor (FXR) ligands have shown promising outcomes in ameliorating insulin resistance associated with various medical conditions. This study aimed to investigate...

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Bibliographic Details
Main Authors: Firas H. Bazzari, Dalaal M. Abdallah, Hanan S. El-Abhar
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
Alzheimer’s disease
insulin resistance
chenodeoxycholic acid
Aβ<sub>42</sub>
BACE1
IRS-1/Akt/GLUT4
CREB/BDNF
GLP-1
PPARγ
Online Access:https://www.mdpi.com/1420-3049/24/10/1992

Internet

https://www.mdpi.com/1420-3049/24/10/1992

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