Design, Synthesis and in Vivo Anti-inflammatory Activities of 2,4-Diaryl-5-4H-imidazolone Derivatives

Design, Synthesis and in Vivo Anti-inflammatory Activities of 2,4-Diaryl-5-4H-imidazolone Derivatives

A series of 2,4-diaryl-5(4H)-imidazolones were prepared and evaluated for their anti-inflammatory activities. Some selected 2,4-diaryl-5(4H)-imidazolones exhibited excellent anti-inflammatory activity in the carrageenan-induced rat paw edema model. Structure Activity Relationships within the series...

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Bibliographic Details
Main Authors: Abdel-Ghany H. El-Helby, Asharf A. Abdel-Rahman, Hassanein H. Hassanein, Moustafa El-Araby, Abdelsattar Omar
Format: Article
Language:English
Published: MDPI AG 2012-10-01
Series:Molecules
Subjects:
anti-inflammatory
COX-2
COX-2 inhibitors
imidazolone
oxazolone
docking
structure-based design
Online Access:http://www.mdpi.com/1420-3049/17/10/12262

Internet

http://www.mdpi.com/1420-3049/17/10/12262

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