Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection.

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection.

Mutations in Cu/Zn superoxide dismutase 1 (SOD1) associated with familial amyotrophic lateral sclerosis cause the protein to aggregate via a prion-like process in which soluble molecules are recruited to aggregates by conformational templating. These misfolded SOD1 proteins can propagate aggregation...

Full description

Bibliographic Details
Main Authors: Anthony Crown, Luke McAlary, Eric Fagerli, Hilda Brown, Justin J Yerbury, Ahmad Galaleldeen, Neil R Cashman, David R Borchelt, Jacob I Ayers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0227655

Internet

https://doi.org/10.1371/journal.pone.0227655

Similar Items