Bi-directional regulation of cartilage metabolism by inhibiting BET proteins—analysis of the effect of I-BET151 on human chondrocytes and murine joints

Bi-directional regulation of cartilage metabolism by inhibiting BET proteins—analysis of the effect of I-BET151 on human chondrocytes and murine joints

Abstract Background Proinflammatory cytokines, which can upregulate the expression of matrix-degrading enzymes in chondrocytes, play important roles in the development of osteoarthritis. And a BET protein inhibitor, I-BET151, has been shown to exert an anti-inflammatory effect by repressing the BET...

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Bibliographic Details
Main Authors: Jin Dai, Sheng Zhou, Qiting Ge, Jinzhong Qin, Dongyang Chen, Zhihong Xu, Dongquan Shi, Jianxin Li, Huangxian Ju, Yi Cao, Minghao Zheng, Chao Jun Li, Xiang Gao, Huajian Teng, Qing Jiang
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Osteoarthritis
Chondrodyte
Matrix-degrading enzymes
Cartilage anabolism
Brd
Online Access:http://link.springer.com/article/10.1186/s13018-018-0797-y

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http://link.springer.com/article/10.1186/s13018-018-0797-y

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