Total glucosides of paeony protects THP-1 macrophages against monosodium urate-induced inflammation via MALAT1/miR-876-5p/NLRP3 signaling cascade in gouty arthritis

Total glucosides of paeony protects THP-1 macrophages against monosodium urate-induced inflammation via MALAT1/miR-876-5p/NLRP3 signaling cascade in gouty arthritis

Background: Monosodium urate (MSU)-mediated inflammatory response is a crucial inducing factor in gouty arthritis. Here, we explored the underlying mechanism of total glucosides of paeony (TGP) in MSU-induced inflammation of THP-1 macrophages in gouty arthritis. Methods: 3-(4,5-Dimethylthiazol-2-yl)...

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Bibliographic Details
Main Authors: Qingliang Meng, Wanting Meng, Hua Bian, Fuzeng Zheng, Huimin Gu, Ruiting Zuo, Xiyun Miao, Zipeng Zhou, Liying Wang, Zhike Wen, Junfu Ma, Xiao Su
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Gouty arthritis
Monosodium urate
Total glucosides of paeony
MALAT1
MiR-876-5p
NLRP3
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221001980

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http://www.sciencedirect.com/science/article/pii/S0753332221001980

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