Contact System Activation in Plasma from Dengue Patients Might Harness Endothelial Virus Replication through the Signaling of Bradykinin Receptors

Contact System Activation in Plasma from Dengue Patients Might Harness Endothelial Virus Replication through the Signaling of Bradykinin Receptors

Since exacerbated inflammation and microvascular leakage are hallmarks of dengue virus (DENV) infection, here we interrogated whether systemic activation of the contact/kallikrein-kinin system (KKS) might hamper endothelial function. In vitro assays showed that dextran sulfate, a potent contact acti...

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Bibliographic Details
Main Authors: Sharton V. A. Coelho, Naiara M. Rust, Lucas Vellasco, Michelle P. Papa, Aline S. G. Pereira, Matheus Ferreira da Silva Palazzo, Maria Aparecida Juliano, Simone M. Costa, Ada M. B. Alves, Marli T. Cordeiro, Ernesto T. A. Marques, Júlio Scharfstein, Luciana B. de Arruda
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pharmaceuticals
Subjects:
dengue
bradykinin
endothelial cells
kallikrein-kinin system
contact pathway
bradykinin receptor B2
Online Access:https://www.mdpi.com/1424-8247/14/1/56

Internet

https://www.mdpi.com/1424-8247/14/1/56

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