ALS-Associated SOD1(G93A) Decreases SERCA Pump Levels and Increases Store-Operated Ca<sup>2+</sup> Entry in Primary Spinal Cord Astrocytes from a Transgenic Mouse Model

ALS-Associated SOD1(G93A) Decreases SERCA Pump Levels and Increases Store-Operated Ca<sup>2+</sup> Entry in Primary Spinal Cord Astrocytes from a Transgenic Mouse Model

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective death of motor neurons (MNs), probably by a combination of cell- and non-cell-autonomous processes. The past decades have brought many important insights into the role of astrocytes in nervous sy...

Full description

Bibliographic Details
Main Authors: Rosa Pia Norante, Caterina Peggion, Daniela Rossi, Francesca Martorana, Agnese De Mario, Annamaria Lia, Maria Lina Massimino, Alessandro Bertoli
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
amyotrophic lateral sclerosis
astrocytes
ca<sup>2+</sup> signaling
store-operated ca<sup>2+</sup> entry
endoplasmic reticulum
serca
transgenic mice
stim
orai
Online Access:https://www.mdpi.com/1422-0067/20/20/5151

Internet

https://www.mdpi.com/1422-0067/20/20/5151

Similar Items