Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage

Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage

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We report a novel technology for the rapid healing of large osseous and chondral defects, based upon the genetic modification of autologous skeletal muscle and fat grafts. These tissues were selected because they not only possess mesenchymal progenitor cells and scaffolding properties, but also can...

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Bibliographic Details
Main Authors: CH Evans, F-J Liu, V Glatt, JA Hoyland, C Kirker-Head, A Walsh, O Betz, JW Wells, V Betz, RM Porter, FA Saad, LC Gerstenfeld, TA Einhorn, MB Harris, MS Vrahas
Format: Article
Language:English
Published: AO Research Institute Davos 2009-12-01
Series:European Cells & Materials
Subjects:
Adenovirus
bone morphogenetic protein
large segmental defects
cartilage repair
bone healing
gene therapy
animal models
facilitated endogenous repair
tissue engineering
fibrodysplasia ossificans progressiva
Online Access:http://www.ecmjournal.org/journal/papers/vol018/pdf/v018a09.pdf

Internet

http://www.ecmjournal.org/journal/papers/vol018/pdf/v018a09.pdf

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