Development of an Antigen-Antibody Co-Display System for Detecting Interaction of G-Protein-Coupled Receptors and Single-Chain Variable Fragments

Development of an Antigen-Antibody Co-Display System for Detecting Interaction of G-Protein-Coupled Receptors and Single-Chain Variable Fragments

G-protein-coupled receptors (GPCRs), especially chemokine receptors, are ideal targets for monoclonal antibody drugs. Considering the special multi-pass transmembrane structure of GPCR, it is often a laborious job to obtain antibody information about off-targets and epitopes on antigens. To accelera...

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Bibliographic Details
Main Authors: Yinjie Zhang, Boyang Jason Wu, Xiaolan Yu, Ping Luo, Hao Ye, Yan Yu, Wei Han, Jingjing Li
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
yeast two hybrid
G protein coupled receptor
antibodies
off-targets
epitope
Online Access:https://www.mdpi.com/1422-0067/22/9/4711

Internet

https://www.mdpi.com/1422-0067/22/9/4711

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