Chorioamnionitis induces hepatic inflammation and time-dependent changes of the enterohepatic circulation in the ovine fetus

Abstract Chorioamnionitis, inflammation of fetal membranes, is an important cause of preterm birth and a risk factor for the development of adverse neonatal outcomes including sepsis and intestinal pathologies. Intestinal bile acids (BAs) accumulation and hepatic cytokine production are involved in...

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Bibliographic Details
Main Authors: Cathelijne Heymans, Marcel den Dulk, Kaatje Lenaerts, Lara R. Heij, Ilse H. de Lange, Mhamed Hadfoune, Chantal van Heugten, Boris W. Kramer, Alan H. Jobe, Masatoshi Saito, Matthew W. Kemp, Tim G. A. M. Wolfs, Wim G. van Gemert
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-89542-4