B7 / CD28 in central tolerance: costimulation promotes maturation of regulatory T cell precursors and prevents their clonal deletion

B7 / CD28 in central tolerance: costimulation promotes maturation of regulatory T cell precursors and prevents their clonal deletion

According to the two-step model, the intrathymic generation of CD4+ regulatory T (Treg) cells segregates into a first, T cell receptor (TCR)-driven phase and a second, cytokine dependent phase. The initial TCR stimulus gives rise to a CD25+Foxp3– developmental intermediate. These precursors subseque...

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Bibliographic Details
Main Authors: Maria eHinterberger, Gerald eWirnsberger, Ludger eKlein
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-07-01
Series:Frontiers in Immunology
Subjects:
tolerance
Regulatory T Cell
CD28
costimulation
Thymus
B7
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00030/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00030/full

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