Repeated Administration of Ketamine can Induce Hippocampal Neurodegeneration and Long-Term Cognitive Impairment via the ROS/HIF-1α Pathway in Developing Rats

Repeated Administration of Ketamine can Induce Hippocampal Neurodegeneration and Long-Term Cognitive Impairment via the ROS/HIF-1α Pathway in Developing Rats

Background: Recent animal experiments have suggested that ketamine administration during development might induce widespread neurodegeneration and long-term cognitive deficits. The underlying mechanism is not fully understood. Methods: Immature rat hippocampal neurons and newborn rats underwent repe...

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Bibliographic Details
Main Authors: Jia Yan, Yan Huang, Yi Lu, Jie Chen, Hong Jiang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Neurotoxicity
Apoptosis
Anesthesia
Ketamine
Hypoxia-inducible factor- 1α
Infant
Online Access:http://www.karger.com/Article/FullText/362953

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http://www.karger.com/Article/FullText/362953

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