PAI-1-dependent endothelial cell death determines severity of radiation-induced intestinal injury.

PAI-1-dependent endothelial cell death determines severity of radiation-induced intestinal injury.

Normal tissue toxicity still remains a dose-limiting factor in clinical radiation therapy. Recently, plasminogen activator inhibitor type 1 (SERPINE1/PAI-1) was reported as an essential mediator of late radiation-induced intestinal injury. However, it is not clear whether PAI-1 plays a role in acute...

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Bibliographic Details
Main Authors: Rym Abderrahmani, Agnes François, Valerie Buard, Georges Tarlet, Karl Blirando, Mohammad Hneino, Aurelie Vaurijoux, Marc Benderitter, Jean-Christophe Sabourin, Fabien Milliat
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3338537?pdf=render

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http://europepmc.org/articles/PMC3338537?pdf=render

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